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KMID : 0385219960060010028
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Korean Journal of Gerontology
1996 Volume.6 No. 1 p.28 ~ p.34
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Effect of Aloe on Learning and Memory Impairment Animal Model SAMP8 - I. Feeding Effect of Aloe on Anti-aging Action of SAMP-8 Brain
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Choi Jin-Ho
Kim Dong-Woo
Han Young-Sil
Yoo Je-Kwon
Han Sang-Seop
Shim Chang-Sub
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Abstract
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This study was designed to investigate the effects of aloe in anti-aging, action of SMAP8 brain such as inhibitory effects of grading score of senescence, free radical, malondialdyhyde and lipofuscin formations, malondialdyhyde content, and increasing effects of scavenger enzyme activities such as superoxide dismutase(Mn-SOD; Cu,Zn-SOD) and glutahione peroxidase(GSH-Px). SAMP8 as a learning and memory impairment animal model were fed basic or experimental diets with 1.0% of freeze dried(FD)-aloe(Aloe vera LINNE) for 8 months. Grading score of senescence resulted in a marked decrease of 20% in 1.0% aloe-added group compared with control group. Formations of superoxide radical and hydroxyl radical were significantly decreased in 15 and 25%, respectively, by administration of 1.0% aloe. Administration of 1.0% aloe resulted in a marked decrease in malondialdehyde(MDA) levels of 20% and 15% in mitochondria and microsome, respectively, and also significantly decreased in 25% of lipofuscin accumulation in brain membrane of SAMP8. Administration of 1.0% aloe resulted in a marked increase in 20% of Mn-SOD activity in microsome and 25% of Cu, Zn-SOD activity in cytosol of SAMP8 brain, but GSH-Px activity in cytosol of SMAP8 brain slightly increased by administration of 1.0% aloe. These results suggest that brain aging, and learning and memory impairments of SAMP8 may be effectively inhibited by chronic administration of aloe for 8 months.
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KEYWORD
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Aloe vera, reactive oxygen species(ROS), malondialdehyde, anti-aging, scavenger enzyme, Mn-SOD, Cu, Zn-SOD, GSH-Px
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